In Vivo Research

We conduct advanced in vivo studies on animal models in full compliance with applicable regulations and with the approval of the relevant ethics committee for animal experimentation. These studies provide a comprehensive assessment of the safety and efficacy of bioactive substances, their effects on living organisms, and their potential applications in regenerative medicine and supplementation.

Scope of in vivo research includes:

✓ Assessment of the impact of bioactive substances on the microbiome – carried out using the guinea pig model (Cavia porcellus), an animal with a well-developed and sensitive gut microbiota, similar to that of humans. These studies allow for:
• analysis of microbiota composition changes after substance administration,
• evaluation of microbial balance modulation,
• identification of potential probiotic or prebiotic properties.

✓ rDNA typing (ribotyping) – we use advanced ribosomal DNA sequencing techniques to detect changes in microbial populations, which enables:
• species-level identification of microorganisms,
• comparison of microbial profiles before and after intervention,
• correlation of microbiome changes with biological effects of the tested substance.

✓ Bioefficacy testing of implants and biomaterials – we conduct experimental implantation of biomaterials in the cranial bone model of Wistar rats, allowing for:
• evaluation of biocompatibility and local tissue response,
• assessment of osteointegration processes,
• analysis of the bioefficacy of materials used in bone reconstruction,
• testing of formulations supporting hard tissue regeneration.

✓ Toxicity and safety assessment – including evaluation of systemic tolerance, hematological and histopathological parameters, and behavioral observations. These tests are essential for determining the safety profile of new formulations intended for human or animal use.

We provide:

✓ Full compliance with the highest ethical standards (ethics committee approvals, EU directive compliance);
✓ Tailored study protocol design;
✓ Experienced research team and animal technicians;
✓ Integration of in vivo data with in vitro and molecular analyses;
✓ Professional final reports and support in preparing publications or registration documentation.

Who is it for?

✓ Pharmaceutical companies;
✓ Producers of dietary supplements and functional foods;
✓ Biomaterials and implantology industry;
✓ Research and scientific institutions;
✓ Biotechnology start-ups.